ANTIMICROBIAL POTENTIAL OF LACTIC ACID BACTERIA LACTOBACILLUS RHAMNOSUS LYSATE

According to World Health Organization, antibiotic resistance is rising dangerously high levels in all parts of the world. New mechanisms are emerging and spreading globally, threatening our ability treat common infectious diseases. Therefore, searching for new antimicrobial agents natural origin an extraordinary global problem. The work aimed determine activity lyophilized enzymatic lysate cells Lactobacillus rhamnosus V strain lactic acid bacteria. object study was drug Del-Imun V®, which hasanti-allergican dimmuno stimulating activity. researchers' efforts fully reveal drug's potential, particularlyitsanti microbialaction. Antimicrobial determined by minimum inhibitory concentration (MIC). Determination MIC carried out method twotime serial dilutions meat-peptone broth (MPB) bacteria liquid wort yeast. Gram-negative (Escherichia coli IEM-1, Proteus vulgaris PA-12, Pseudomonas sp. MI-2) Gram-positive (Bacillus subtilis BТ-2, Staphylococcus aureus BМС-1) bacteria, as well yeast (Candida albicans D-6, Candida tropicalis PE-2, utilis BVS-65). It shown that valuesof native preparation bacterial test cultures (EscherichiacoliIEM-1, Bacillussubtilis BT-2, Staphylococcusaureus BMS-1, Proteusvulgaris Pseudomonassp. were 8 time slower, than those thermally activated preparation, forthe yeasts (Candidaalbicans Candidatropicalis Candidautilis BVS-65) – 4-8 slower. As a result conducted research, antibacterial antifungal drugDel-Imun V® established. spectrum concerned gram-positiveand gram-negative yeast-like fungi genus Candida. concentrations quite low: from 1.0 4.0 μg/ml 62.5 125 culture B. BT-2 least sensitive action (MIC 12.5 μg/ml). There fore, it can be concluded lacticacid bacteriahasanti landanti fungal properties.